Noël Agnès, Jost Maud, Maquoi Erik
Laboratory of Tumor and Development Biology, Centre de Recherche en Cancérologie Expérimentale (CRCE), Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-R), University of Liege, Sart-Tilman, Liège, Belgium.
Semin Cell Dev Biol. 2008 Feb;19(1):52-60. doi: 10.1016/j.semcdb.2007.05.011. Epub 2007 Jun 6.
The increasing diversity in both substrates and functions of matrix metalloproteinases (MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their microenvironment. In the majority of cancers, membrane-associated and extracellular proteases are mainly produced by host cells including inflammatory cells, endothelial cells, pericytes and fibroblasts. Recent data based on in vitro and in vivo studies have demonstrated the relevance of these enzymes in multiple processes controlling cancer growth, angiogenesis and metastatic dissemination. This review will present the emerging MMP-related features of cancer cells and host cells.
基质金属蛋白酶（MMPs）底物和功能的多样性不断增加，使其成为由癌细胞及其微环境组成的复杂肿瘤生态系统中的核心调节因子。在大多数癌症中，膜相关蛋白酶和细胞外蛋白酶主要由包括炎症细胞、内皮细胞、周细胞和成纤维细胞在内的宿主细胞产生。基于体外和体内研究的最新数据表明，这些酶在控制癌症生长、血管生成和转移扩散的多个过程中具有相关性。本综述将介绍癌细胞和宿主细胞中与MMP相关的新特征。
