Onyiba Cosmos Ifeanyi, Scarlett Christopher J, Weidenhofer Judith
School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Ourimbah, NSW 2258, Australia.
School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Ourimbah, NSW 2258, Australia.
Cancers (Basel). 2022 Oct 19;14(20):5118. doi: 10.3390/cancers14205118.
Mammalian sirtuins (SIRT1-7) are involved in a myriad of cellular processes, including apoptosis, proliferation, differentiation, epithelial-mesenchymal transition, aging, DNA repair, senescence, viability, survival, and stress response. In this review, we discuss the current information on the mechanistic roles of SIRT1-7 and their downstream effects (tumor promotion or suppression) in cancers of the breast and prostate. Specifically, we highlight the involvement of sirtuins in the regulation of various proteins implicated in proliferation, apoptosis, autophagy, chemoresistance, invasion, migration, and metastasis of breast and prostate cancer. Additionally, we highlight the available information regarding SIRT1-7 regulation by miRNAs, laying much emphasis on the consequences in the progression of breast and prostate cancer.
哺乳动物的沉默调节蛋白（SIRT1 - 7）参与众多细胞过程，包括细胞凋亡、增殖、分化、上皮 - 间充质转化、衰老、DNA修复、细胞衰老、活力、存活及应激反应。在本综述中，我们讨论了目前关于SIRT1 - 7的机制作用及其在乳腺癌和前列腺癌中的下游效应（肿瘤促进或抑制）的信息。具体而言，我们着重介绍了沉默调节蛋白在调节与乳腺癌和前列腺癌的增殖、凋亡、自噬、化疗耐药、侵袭、迁移及转移相关的各种蛋白质中的作用。此外，我们强调了有关miRNA对SIRT1 - 7调节的现有信息，重点阐述了其在乳腺癌和前列腺癌进展中的影响。
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