健康但结核菌素纯蛋白衍生物反应阳性儿童中抗16千道尔顿分枝杆菌蛋白免疫球蛋白M水平在化学预防后降低。
Anti-16-kilodalton mycobacterial protein immunoglobulin m levels in healthy but purified protein derivative-reactive children decrease after chemoprophylaxis.
作者信息
Sireci Guido, Dieli Francesco, Di Liberto Diana, Buccheri Simona, La Manna Marco Pio, Scarpa Francesco, Macaluso Pasquale, Romano Amelia, Titone Lucina, Di Carlo Paola, Singh Mahavir, Ivanyi Jurayi, Salerno Alfredo
机构信息
Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italy.
出版信息
Clin Vaccine Immunol. 2007 Sep;14(9):1231-4. doi: 10.1128/CVI.00057-07. Epub 2007 Jul 11.
Abstract
Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M. tuberculosis HSP16 responses could assist in the management of pediatric TB.
摘要
对患有结核病（TB）的儿童以及健康的纯化蛋白衍生物（PPD）阳性和PPD阴性儿童测定了针对结核分枝杆菌HSP16的血清反应。结核病患者的免疫球蛋白G（IgG）和IgM反应高于其他组。化疗后，结核病患者和PPD阳性受试者的IgM和IgG反应下降。监测抗结核分枝杆菌HSP16反应有助于儿童结核病的管理。
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