Bernstein Anke, Nöbel Doreen, Mayr Hermann O, Berger Georg, Gildenhaar Renate, Brandt Jörg
Laboratory of Experimental Orthopedics, Department of Orthopedics, Martin Luther University of Halle-Wittenberg, Magdeburger Strasse 22, 06097 Halle, Germany.
J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):452-62. doi: 10.1002/jbm.b.30891.
Resorbable ceramics can promote the bony integration of implants. Their rate of degradation should ideally be synchronized with bone regeneration. We report here the results of a histological study of implants with two resorbable calcium phosphate ceramic coatings: Ca(2)KNa(PO(4))(2)-(GB14) and Ca(10)K/Na(7)-(602020). The results attained with these ceramic-coated implants show the benefits of these materials with regard to bioactive bone-healing stimulation, compared with uncoated implants. The GB14 ceramic coating exhibited greater bone regeneration and differentiation on its surface than the conventional hydroxyapatite coating and helped bone tissue achieve more extensive contact free of connective tissue. Not until the coating disintegrated did the histological features of GB14- and 602020-coated implants converge-both implant types were integrated into bone. Rapid disintegration of the coating material, as with 602020, supports osteoblast proliferation but has negative effects on bone mineralization. Both resorbable ceramics tested, GB14 and 602020, demonstrated bioactivity; even metal surfaces coated with these materials were populated by mature bone tissue without connective tissue after disintegration of their ceramic coating. The less rapidly degrading material, GB14, achieved better results. Degradable calcium phosphate coatings have the potential to stimulate bone regeneration. From the histological viewpoint, the resorbable ceramics examined here can be recommended as coating materials for clinical use.
可吸收陶瓷可促进种植体的骨整合。理想情况下，它们的降解速率应与骨再生同步。我们在此报告了一项组织学研究的结果，该研究针对两种可吸收磷酸钙陶瓷涂层的种植体：Ca(2)KNa(PO(4))(2)-(GB14)和Ca(10)K/Na(7)-(602020)。与未涂层的种植体相比，这些陶瓷涂层种植体所获得的结果显示了这些材料在生物活性骨愈合刺激方面的优势。GB14陶瓷涂层在其表面展现出比传统羟基磷灰石涂层更大的骨再生和分化，并有助于骨组织实现更广泛的无结缔组织接触。直到涂层分解，GB14和602020涂层种植体的组织学特征才趋同——两种种植体类型均整合入骨。涂层材料的快速分解，如602020涂层，支持成骨细胞增殖，但对骨矿化有负面影响。所测试的两种可吸收陶瓷GB14和602020均表现出生物活性；甚至涂有这些材料的金属表面在其陶瓷涂层分解后也被成熟的骨组织所占据，且无结缔组织。降解较慢的材料GB14取得了更好的结果。可降解磷酸钙涂层有刺激骨再生的潜力。从组织学角度来看，此处所研究的可吸收陶瓷可推荐作为临床使用的涂层材料。
