Schwartz R S, Donnelly J, Melief C J, Louie S
J Immunol. 1976 Mar;116(3):657-60.
A combined virologic and immunologic study was done in mice that were either naturally or deliberately infected with C-type RNA viruses. In about 60% of B10. A mice, natural infection was accompanied by detectable anti-VEA antibodies in the serum. The absence of such antibodies was a reliable indicator of the absence of virus in B10 mice. Deliberately infected young adult B10 mice failed to eliminate the virus completely, despite high titers of anti-VEA antibodies. B10 mice exposed to B tropic viruses at birth made anti-VEA antibodies but failed to eliminate the virus. By contrast, some NIH Swiss mice exposed to N-tropic virus at birth made anti-VEA antibodies and eliminated the virus.
对自然感染或经人工感染C型RNA病毒的小鼠进行了病毒学和免疫学联合研究。在约60%的B10.A小鼠中，自然感染伴有血清中可检测到的抗VEA抗体。此类抗体的缺失是B10小鼠体内无病毒的可靠指标。尽管抗VEA抗体效价很高，但经人工感染的成年B10小鼠未能完全清除病毒。出生时接触嗜B性病毒的B10小鼠产生了抗VEA抗体，但未能清除病毒。相比之下，一些出生时接触嗜N性病毒的NIH瑞士小鼠产生了抗VEA抗体并清除了病毒。
