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高、低乳腺癌发病率小鼠品系对小鼠乳腺肿瘤病毒的自身免疫。

Autogenous immunity to mouse mammary tumor virus in mouse strains of high and low mammary tumor incidence.

作者信息

Ihle J N, Arthur L O, Fine D L

出版信息

Cancer Res. 1976 Aug;36(8):2840-4.

PMID:179709
Abstract

Specific radioimmune precipitation assays were utilized to demonstrate the presence of precipitating antibodies to mouse mammary tumor virus (MMTV) in the high-spontaneous mammary tumor strains of mice: C3H/HeN+, GR/N, BALB/cfC3H, and C57BL/6 X C3H F1 (hereafter called B6C3F1). Antibody titers in C3H/HeN+ mice increased with age, with highest titers observed in tumor-bearing animals. MMTV-precipitating antibodies were not detectable by radioimmune precipitation assay in low-mammary tumor strains (AKR, BALB/c C57BL/6, and C3H/HeN-) but were detectable in MMTV-inoculated BALB/c mice. Appearance of antibodies preceded palpable tumor formation, and antibody titers were directly correlated to virus dose. Natural antibody to MMTV in C3H/HeN+ and B6C3F1 mice coexists with the murine leukemia virus natural antibody as determined by competition radioimmunoassays.

摘要

利用特异性放射免疫沉淀试验来证明在高自发性乳腺肿瘤小鼠品系（C3H/HeN+、GR/N、BALB/cfC3H和C57BL/6×C3H F1，以下称为B6C3F1）中存在针对小鼠乳腺肿瘤病毒（MMTV）的沉淀抗体。C3H/HeN+小鼠中的抗体滴度随年龄增加，在患肿瘤动物中观察到最高滴度。在低乳腺肿瘤品系（AKR、BALB/c C57BL/6和C3H/HeN-）中，通过放射免疫沉淀试验无法检测到MMTV沉淀抗体，但在接种MMTV的BALB/c小鼠中可以检测到。抗体的出现先于可触及肿瘤的形成，并且抗体滴度与病毒剂量直接相关。通过竞争放射免疫测定法确定，C3H/HeN+和B6C3F1小鼠中针对MMTV的天然抗体与鼠白血病病毒天然抗体共存。

相似文献

1
Autogenous immunity to mouse mammary tumor virus in mouse strains of high and low mammary tumor incidence.高、低乳腺癌发病率小鼠品系对小鼠乳腺肿瘤病毒的自身免疫。
Cancer Res. 1976 Aug;36(8):2840-4.
2
Immunoelectron microscopic studies of antibodies in mouse sera directed against mouse mammary tumor virus.针对小鼠乳腺肿瘤病毒的小鼠血清中抗体的免疫电子显微镜研究。
Cancer Res. 1977 Jul;37(7 Pt 1):2086-91.
3
Autogenous antibodies against the murine mammary tumor virus in strains of mice with low incidences of mammary tumors.在乳腺肿瘤发病率较低的小鼠品系中，针对小鼠乳腺肿瘤病毒的自身抗体。
J Natl Cancer Inst. 1979 Apr;62(4):935-41.
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Murine mammary tumor virus seroepidemiology in BALB/cfC3H mice: correlation with tumor development.BALB/cfC3H小鼠的鼠乳腺肿瘤病毒血清流行病学：与肿瘤发生的相关性
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Cellular immunity to mammary tumor virus in normal and tumor-bearing C3H/HeN mice.正常及患瘤C3H/HeN小鼠对乳腺肿瘤病毒的细胞免疫
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C3H/HeN mammary tumor-bearing mice develop type-specific neutralizing antibodies and group-specific precipitating antibodies for the mouse mammary tumor virus.携带C3H/HeN乳腺肿瘤的小鼠会产生针对小鼠乳腺肿瘤病毒的型特异性中和抗体和组特异性沉淀抗体。
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B and T cells are required for mouse mammary tumor virus spread within the mammary gland.B细胞和T细胞是小鼠乳腺肿瘤病毒在乳腺内传播所必需的。
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Characteristics of mammary tumor cultures from four mouse strains infected with mammary tumor virus.感染乳腺肿瘤病毒的四种小鼠品系的乳腺肿瘤培养物的特征
Cancer Res. 1975 Feb;35(2):370-3.

引用本文的文献

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Mouse mammary tumor virus and its interaction with the immune system.小鼠乳腺肿瘤病毒及其与免疫系统的相互作用。
Immunol Res. 1998;17(1-2):209-16. doi: 10.1007/BF02786445.
2
Natural and induced immunity to mouse mammary tumors and the mammary tumor virus (MuMTV).对小鼠乳腺肿瘤和乳腺肿瘤病毒（MuMTV）的天然免疫和诱导免疫。
Springer Semin Immunopathol. 1982;4(4):333-72. doi: 10.1007/BF02053739.
3
Effect of the age-related immune depression induced by MTV on the in vivo growth of a mammary carcinoma.MTV诱导的与年龄相关的免疫抑制对乳腺癌体内生长的影响。
Br J Cancer. 1981 Sep;44(3):460-3. doi: 10.1038/bjc.1981.206.
4
Virus-specific cytotoxic activity to mammary tumor cells of sera from normal and tumor-bearing mice with inhibition at low dilutions.正常小鼠和荷瘤小鼠血清对乳腺肿瘤细胞的病毒特异性细胞毒性活性，在低稀释度时有抑制作用。
Infect Immun. 1981 Apr;32(1):15-23. doi: 10.1128/iai.32.1.15-23.1981.
5
Monoclonal antibodies identify individual determinants on mouse mammary tumor virus glycoprotein gp52 with group, class, or type specificity.单克隆抗体可识别小鼠乳腺肿瘤病毒糖蛋白gp52上具有组、类或型特异性的单个决定簇。
J Virol. 1980 Jun;34(3):635-43. doi: 10.1128/JVI.34.3.635-643.1980.
6
C3H/HeN mammary tumor-bearing mice develop type-specific neutralizing antibodies and group-specific precipitating antibodies for the mouse mammary tumor virus.携带C3H/HeN乳腺肿瘤的小鼠会产生针对小鼠乳腺肿瘤病毒的型特异性中和抗体和组特异性沉淀抗体。
J Virol. 1980 Jan;33(1):123-8. doi: 10.1128/JVI.33.1.123-128.1980.
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Identification and characterization of a mouse mammary tumor virus protein uniquely expressed on the surface of BALB/cV mammary tumor cells.一种在BALB/cV乳腺肿瘤细胞表面独特表达的小鼠乳腺肿瘤病毒蛋白的鉴定与特性分析。
Virology. 1985 May;143(1):127-42. doi: 10.1016/0042-6822(85)90102-3.
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Arch Virol. 1990;113(1-2):35-52. doi: 10.1007/BF01318351.
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Membrane fluidity, capping of cell-surface antigens and immune response in mouse leukaemia cells.小鼠白血病细胞膜流动性、细胞表面抗原的帽化及免疫反应
Br J Cancer. 1978 Mar;37(3):329-36. doi: 10.1038/bjc.1978.51.
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Mice with spontaneous mammary tumors develop type-specific neutralizing and cytotoxic antibodies against the mouse mammary tumor virus envelope protein gp52.患有自发性乳腺肿瘤的小鼠会产生针对小鼠乳腺肿瘤病毒包膜蛋白gp52的类型特异性中和抗体和细胞毒性抗体。
J Virol. 1979 Oct;32(1):131-9. doi: 10.1128/JVI.32.1.131-139.1979.