人乳头瘤病毒检测方法。
HPV detection methods.
作者信息
Brink Antoinette A T P, Snijders Peter J F, Meijer Chris J L M
机构信息
VU University Medical Center, Department of Pathology, Section Molecular Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
出版信息
Dis Markers. 2007;23(4):273-81. doi: 10.1155/2007/147429.
Abstract
Given the causal relation between a persistent high-risk human papillomavirus (hrHPV) infection and the development of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer, hrHPV testing has been advocated in addition to cytology for the detection of clinically relevant cervical lesions. HrHPV testing is thought to improve cervical screening algorithms, the management of women with cytologically equivocal smears, and the management of women treated for high grade CIN. In this chapter we discuss different methods for HPV detection and genotyping and their respective applications.
摘要
鉴于持续性高危型人乳头瘤病毒（hrHPV）感染与高级别宫颈上皮内瘤变（CIN）及宫颈癌发生之间的因果关系，除细胞学检查外，还提倡进行hrHPV检测以发现具有临床意义的宫颈病变。hrHPV检测被认为可改善宫颈筛查方案、细胞学涂片结果不明确女性的管理以及高级别CIN治疗女性的管理。在本章中，我们将讨论HPV检测和基因分型的不同方法及其各自的应用。
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