人乳头瘤病毒（HPV）与食管鳞状细胞癌之间存在关联吗？
IS THERE CORRELATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND ESOPHAGEAL EPIDERMOID CARCINOMA?
作者信息
Woellner Luiz Filipe Alkamin, Medeiros Juliano Smaniotto de, Ribas Carmen Australia Paredes Marcondes, Nassif Paulo Afonso Nunes, Ribas-Filho Jurandir Marcondes, Sobral Ana Cristina Lira, Ariede Bruno Luiz, Costa Debora Azeredo Pacheco Dias DA, Malafaia Osvaldo
机构信息
Postgraduate Program in Principles of Surgery, Mackenzie Evangelical Faculty of Paraná, Curitiba, PR, Brazil.
Institute of Medical Research, Faculdade Evangélica Mackenzie do Paraná, Curitiba, PR, Brazil.
出版信息
Arq Bras Cir Dig. 2021 May 14;34(1):e1528. doi: 10.1590/0102-672020200002e1528.
BACKGROUND
Currently, persistent human papillomavirus (HPV) infection has been related in some geographic regions as a risk factor for esophageal squamous cell carcinoma. It results in the immunoexpression of the p16 protein, which has been used as marker of the oncogenic lineage by this etiological agent.
AIM
To correlate epidemiological aspects of esophageal squamous cell carcinoma with the prevalence of HPV infection.
METHODS
Fifty-eight cases were analyzed and submitted to histopathological and immunohistochemical analysis by p16.
RESULTS
Of the 58 cases evaluated, 40 were men and 18 women, with a mean age of 63.2 years. p16 immunoexpression was positive in 46.55%.
CONCLUSION
The prevalence of HPV infection is high in esophageal squamous cell carcinoma presenting in almost half of the cases (46.55%), without gender differentiation.
背景
目前，在一些地理区域，持续性人乳头瘤病毒（HPV）感染已被视为食管鳞状细胞癌的一个风险因素。它会导致p16蛋白的免疫表达，该蛋白已被用作这种病原体致癌谱系的标志物。
目的
将食管鳞状细胞癌的流行病学特征与HPV感染的患病率相关联。
方法
分析了58例病例，并对其进行了组织病理学和p16免疫组织化学分析。
结果
在评估的58例病例中，男性40例，女性18例，平均年龄63.2岁。p16免疫表达阳性率为46.55%。
结论
食管鳞状细胞癌中HPV感染的患病率很高，几乎占病例的一半（46.55%），且无性别差异。
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