波兰人群中MSR1、RNASEL和E-钙黏蛋白基因的DNA变异与前列腺癌

DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland.

作者信息

Cybulski Cezary, Wokołorczyk Dominika, Jakubowska Anna, Gliniewicz Bartłomiej, Sikorski Andrzej, Huzarski Tomasz, Debniak Tadeusz, Narod Steven A, Lubiński Jan

机构信息

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

出版信息

Urol Int. 2007;79(1):44-9. doi: 10.1159/000102913.

DOI:10.1159/000102913

PMID:17627168

Abstract

INTRODUCTION

We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland.

MATERIAL AND METHODS

We sequenced the coding region of these three genes in individuals from Poland and identified five common DNA variants (R462Q and D541E in RNASEL, R293X and P275A in MSR1, and 2076C>T (A692A) in E-cadherin). These five variants and the -160C>A promoter change in E-cadherin were genotyped in 737 prostate cancer cases and 511 controls.

RESULTS

The frequencies of genotyped variants in MSR1, RNASEL and E-cadherin genes in cases and controls were similar. We did not see any association for the studied variants when cases were stratified by age of diagnosis, by family history, by prostate-specific antigen level at the time of diagnosis, by Gleason sore or by tumor stage.

CONCLUSIONS

Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland.

摘要

引言

我们研究了MSR1、RNASEL和E-钙黏蛋白的遗传变异是否会增加波兰男性患前列腺癌的风险。

材料与方法

我们对来自波兰的个体的这三个基因的编码区进行了测序，并鉴定出五个常见的DNA变异（RNASEL中的R462Q和D541E、MSR1中的R293X和P275A以及E-钙黏蛋白中的2076C>T（A692A））。对737例前列腺癌病例和511例对照进行了这五个变异以及E-钙黏蛋白-160C>A启动子变化的基因分型。