Zuo Li, Ren Ke-Wei, Bai Yu, Zhang Li-Feng, Zou Jian-Gang, Qin Xi-Hu, Mi Yuan-Yuan, Okada Atsushi, Yasui Takahiro
Department of Urology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou 213003, China.
Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
Oncotarget. 2017 Sep 5;8(43):75141-75150. doi: 10.18632/oncotarget.20646. eCollection 2017 Sep 26.
The RNASEL gene (2', 5'-oligoisoadenylate synthetase-dependent) encodes a ribonuclease that plays a significant role in the apoptotic and antiviral activities of interferons. Various studies have used polymorphisms in the RNASEL gene to evaluate prostate cancer risk but studies that show an association between RNASEL Arg462Gln (1385G>A, R462Q, rs486907) polymorphism and prostate cancer risk are somewhat inconclusive. To assess the impact of RNASEL Arg462Gln polymorphism on prostate cancer risk, we conducted a meta-analysis of all available studies including 11,522 patients and 10,976 control subjects. The overall results indicated no positive association between the variant and prostate cancer risk. However, in a subgroup analysis by ethnicity, obvious associations were observed in Hispanic Caucasians for allelic contrast (OR = 1.18, 95% CI = 1.00 - 1.39, = 0.010), homozygote comparison (OR = 1.50, 95% CI = 1.02 - 2.20, = 0.001), and the recessive genetic model (OR = 1.44, 95% CI = 1.01 - 2.05, = 0.002) ; and in African descendants for homozygote comparison (OR = 2.59, 95% CI = 1.29 - 5.19, = 0.194) and the recessive genetic model (OR = 2.61, 95% CI = 1.30 - 5.23, = 0.195). In conclusion, the RNASEL Arg462Gln polymorphism may contribute to the risk of developing prostate cancer in African descendants and Hispanic Caucasians. Further larger and well-designed studies are warranted to evaluate this association in detail.
RNASEL基因（2',5'-寡聚异腺苷酸合成酶依赖性）编码一种核糖核酸酶，该酶在干扰素的凋亡和抗病毒活性中发挥重要作用。各种研究已利用RNASEL基因中的多态性来评估前列腺癌风险，但显示RNASEL基因精氨酸462谷氨酰胺（1385G>A，R462Q，rs486907）多态性与前列腺癌风险之间存在关联的研究结果有些不确定。为了评估RNASEL基因精氨酸462谷氨酰胺多态性对前列腺癌风险的影响，我们对所有可用研究进行了荟萃分析，这些研究包括11522例患者和10976例对照受试者。总体结果表明该变异与前列腺癌风险之间无正相关。然而，在按种族进行的亚组分析中，在西班牙裔白种人中观察到等位基因对比（OR = 1.18，95%CI = 1.00 - 1.39，P = 0.010）、纯合子比较（OR = 1.50，95%CI = 1.02 - 2.20，P = 0.001）以及隐性遗传模型（OR = 1.44，95%CI = 1.01 - 2.05，P = 0.002）存在明显关联；在非洲裔后代中，纯合子比较（OR = 2.59，95%CI = 1.29 - 5.19，P = 0.194）以及隐性遗传模型（OR = 2.61，95%CI = 1.30 - 5.23，P = 0.195）存在明显关联。总之，RNASEL基因精氨酸462谷氨酰胺多态性可能会增加非洲裔后代和西班牙裔白种人患前列腺癌的风险。需要进一步开展规模更大且设计良好的研究来详细评估这种关联。
