Ismail M Saleem, Dagerman Karen, Tariot Pierre N, Abbott Shana, Kavanagh Sarah, Schneider Lon S
University of Rochester Medical Center, Program in Neurobehavioral Therapeutics, Monroe Community Hospital, 435 East Henrietta Road, Rochester, NY 14620, USA.
Curr Alzheimer Res. 2007 Jul;4(3):325-35. doi: 10.2174/156720507781077214.
CATIE-AD was a multicenter effectiveness trial of atypical antipsychotics in patients with agitation and psychosis associated with AD who resided in the community. The study enrolled 421 participants. In this paper we present and discuss baseline characteristics of participants (demographics, cognitive, behavioral, and functional assessments), caregivers (demographics and caregiver burden) and settings at randomization. Those enrolled suffered from a wide range of cognitive impairment, were medically complex and experienced acute psychopathology requiring intervention with atypical antipsychotics. Family members providing the equivalent of institutional care experienced significant depression and caregiver burden. With the increasing prevalence of AD, clinicians and health care planners should look into future needs of those AD sufferers who are residing in community.
CATIE-AD是一项针对居住在社区的、患有与阿尔茨海默病相关的激越和精神病的患者进行的非典型抗精神病药物多中心疗效试验。该研究招募了421名参与者。在本文中，我们展示并讨论了参与者的基线特征（人口统计学、认知、行为和功能评估）、照料者（人口统计学和照料者负担）以及随机分组时的情况。入组者患有广泛的认知障碍，医疗情况复杂，且经历了需要使用非典型抗精神病药物干预的急性精神病理学问题。提供相当于机构护理的家庭成员经历了严重的抑郁和照料者负担。随着阿尔茨海默病患病率的不断上升，临床医生和医疗保健规划者应关注那些居住在社区的阿尔茨海默病患者的未来需求。
