Janssen Alzheimer Immunotherapy Research & Development, South San Francisco, CA, USA.
Alzheimers Dement. 2010 Nov;6(6):482-93. doi: 10.1016/j.jalz.2009.09.004.
This article reviews measures of Alzheimer's disease (AD) progression in relation to patient dependence and offers a unifying conceptual framework for dependence in AD. Clinicians typically characterize AD by symptomatic impairments in three domains: cognition, function, and behavior. From a patient's perspective, changes in these domains, individually and in concert, ultimately lead to increased dependence and loss of autonomy. Examples of dependence in AD range from a need for reminders (early AD) to requiring safety supervision and assistance with basic functions (late AD). Published literature has focused on the clinical domains as somewhat separate constructs and has given limited attention to the concept of patient dependence as a descriptor of AD progression. This article presents the concept of dependence on others for care needs as a potential method for translating the effect of changes in cognition, function, and behavior into a more holistic, transparent description of AD progression.
本文综述了与患者依赖相关的阿尔茨海默病（AD）进展的衡量标准，并为 AD 中的依赖提供了一个统一的概念框架。临床医生通常通过认知、功能和行为三个领域的症状损害来描述 AD。从患者的角度来看，这些领域的变化（单独或协同）最终会导致依赖性增加和自主能力丧失。AD 中的依赖的例子包括需要提醒（早期 AD）到需要安全监督和基本功能协助（晚期 AD）。已发表的文献主要关注临床领域，将其视为相对独立的结构，而对患者依赖作为 AD 进展描述符的概念关注较少。本文提出了依赖他人满足护理需求的概念，作为将认知、功能和行为变化的影响转化为更全面、更透明的 AD 进展描述的一种潜在方法。
