卵子捐赠及单枚冻融胚胎移植后发生的单卵三胎妊娠。

Monozygotic triplet pregnancy following egg donation and transfer of single frozen-thawed embryo.

作者信息

Faraj Radwan, Evbuomwan Isaac, Sturgiss Stephen, Aird Ian

机构信息

Centre for Assisted Reproduction, Queen Elizabeth Hospital, Gateshead, Washington.

Cromwell IVF and Fertility Centre, BUPA Hospital, Washington.

出版信息

Fertil Steril. 2008 May;89(5):1260.e9-1260.e12. doi: 10.1016/j.fertnstert.2007.05.008. Epub 2007 Jul 12.

DOI:10.1016/j.fertnstert.2007.05.008

PMID:17628555

Abstract

OBJECTIVE

To describe a case of monozygotic triplet pregnancy following egg donation and the transfer of a single frozen-thawed embryo.

DESIGN

Case report.

SETTING

District general hospital and regional department of fetal medicine in northeast England.

PATIENT(S): A 38-year-old woman with a 2-year history of primary infertility due to severe endometriosis and poor ovarian reserve who conceived after egg donation and transfer of a single frozen-thawed embryo.

INTERVENTION(S): Transfer of a single frozen-thawed embryo and delivery of three identical female infants by emergency caesarean section because of preterm labor at 32 weeks' gestation.

MAIN OUTCOME MEASURE(S): Review of effect of assisted conception on monozygotic twinning rates.

RESULT(S): Healthy outcome for all three infants.

CONCLUSION(S): Assisted reproductive treatments may lead to disturbances in zona pellucida architecture and an increase in monozygotic twinning rates. Couples need to be informed of this and the increased risks associated with these pregnancies before they begin with treatment.

摘要