Han Jee Hye, Park Hye Soon, Kim Jeong A, Kim Seon Mee
Department of Family Medicine, Eulji General Hospital, Eulji University School of Medicine, South Korea.
Atherosclerosis. 2008 Mar;197(1):333-8. doi: 10.1016/j.atherosclerosis.2007.05.021. Epub 2007 Jul 12.
Apolipoprotein B (apoB) concentration reflects the number of atherogenic particles and is closely associated with atherosclerosis. Non-HDL-cholesterol (non-HDL-C) has been considered a therapeutic target for patients with hypertriglyceridemia. We compared the predictive values of apoB and non-HDL-C for the metabolic syndrome (MetS) in 3335 Korean adults (mean age, 45.2 years) who participated consecutively in a health examination in a university hospital. Anthropometry, blood pressure, fasting glucose, lipid profiles and apoB were measured. MetS, as defined by a modification of the NCEP-ATP III criteria, was present in 22.1% of men and 16.1% of women. Among the components of the MetS, triglycerides showed the strongest correlation with apoB (r=0.393, P<0.001 in men, and r=0.326, P<0.001 in women) and non-HDL-C (r=0.376, P<0.001 in men, and r=0.349, P<0.001 in women). When apoB and non-HDL-C were mutually adjusted, the ORs for the MetS of non-HDL-C were not significant. As a function of the quartile of apoB levels, the ORs for the MetS were 2.04 (1.26-3.30), 3.54 (2.11-5.93), and 5.38 (3.16-9.17) in men (P for trend <0.001) and 3.75 (1.42-9.87), 5.55 (2.09-14.69), and 13.41 (5.02-35.79) in women (P for trend <0.001), respectively. These findings indicate that apoB is a better marker than non-HDL-C for identifying the MetS among Koreans.
载脂蛋白B（apoB）浓度反映致动脉粥样硬化颗粒的数量，且与动脉粥样硬化密切相关。非高密度脂蛋白胆固醇（non-HDL-C）已被视为高甘油三酯血症患者的治疗靶点。我们比较了apoB和non-HDL-C对3335名韩国成年人（平均年龄45.2岁）代谢综合征（MetS）的预测价值，这些成年人连续参加了一家大学医院的健康检查。测量了人体测量学指标、血压、空腹血糖、血脂谱和apoB。根据对美国国家胆固醇教育计划成人治疗组第三次报告（NCEP-ATP III）标准的修订定义，MetS在22.1%的男性和16.1%的女性中存在。在MetS的各项组成成分中，甘油三酯与apoB的相关性最强（男性中r=0.393，P<0.001；女性中r=0.326，P<0.001），与non-HDL-C的相关性也最强（男性中r=0.376，P<0.001；女性中r=0.349，P<0.001）。当对apoB和non-HDL-C进行相互校正后，non-HDL-C对MetS的比值比（OR）无统计学意义。作为apoB水平四分位数的函数，男性中MetS的OR分别为2.04（1.26 - 3.30）、3.54（2.11 - 5.93）和5.38（3.16 - 9.17）（趋势P<0.001），女性中分别为3.75（1.42 - 9.87）、5.55（2.09 - 14.69）和13.41（5.02 - 35.79）（趋势P<0.001）。这些发现表明，在韩国人中，apoB是比non-HDL-C更好的用于识别MetS的标志物。
