Toma Tatsuya, Shimokawa Jun, Fukuyama Tohru
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
Org Lett. 2007 Aug 2;9(16):3195-7. doi: 10.1021/ol701432k. Epub 2007 Jul 13.
A novel entry to the synthesis of diazoacetates is disclosed. A variety of diazoacetates were synthesized from the corresponding bromoacetates by treatment with N,N'-ditosylhydrazine in moderate to high yields. Ease of operation with the stable crystalline reagent as well as a short reaction time offer a useful alternative to the conventional methods.
公开了一种合成重氮乙酸酯的新方法。通过用N,N'-二对甲苯磺酰肼处理相应的溴乙酸酯，以中等到高的产率合成了多种重氮乙酸酯。使用稳定的结晶试剂操作简便，反应时间短，为传统方法提供了一种有用的替代方法。
