De Dea Lindner Juliano, Canchaya Carlos, Zhang Ziding, Neviani Erasmo, Fitzgerald Gerald F, van Sinderen Douwe, Ventura Marco
Department of Genetics, Anthropology and Evolution, University of Parma, parco Area delle Scienze 11a, 43100 Parma, Italy.
Int J Food Microbiol. 2007 Nov 30;120(1-2):13-24. doi: 10.1016/j.ijfoodmicro.2007.06.016. Epub 2007 Jun 14.
Bifidobacteria represent important human commensals because of their perceived contribution to the maintenance of a balanced gastro intestinal tract (GIT). In recent years bifidobacteria have drawn much scientific attention because of their use as live bacteria in numerous food preparations with various health-related claims. For such reasons these bacteria constitute a growing area of interest with respect to genomics, molecular biology and genetics. This review will discuss the current knowledge on the molecular players that allow bifidobacteria to contend with heat-, osmotic-, bile-and acidic stress. Here, we describe the principal molecular chaperones involved in such stresses, as well as their use as phylogenetic markers for gaining insight into the evolutionary history of high G+C Gram positive bacteria.
双歧杆菌是重要的人体共生菌，因为它们被认为有助于维持胃肠道（GIT）的平衡。近年来，双歧杆菌因其作为活菌用于众多具有各种健康相关宣称的食品制剂中而备受科学关注。由于这些原因，这些细菌在基因组学、分子生物学和遗传学方面构成了一个日益受关注的领域。本综述将讨论关于使双歧杆菌能够应对热、渗透、胆汁和酸性应激的分子作用因子的现有知识。在此，我们描述了参与此类应激的主要分子伴侣，以及它们作为系统发育标记物用于深入了解高G+C革兰氏阳性菌进化历史的用途。
