Ventura Marco, O'Connell-Motherway Mary, Leahy Sinead, Moreno-Munoz Jose Antonio, Fitzgerald Gerald F, van Sinderen Douwe
Department of Genetics, Anthropology and Evolution, University of Parma, Italy.
Int J Food Microbiol. 2007 Nov 30;120(1-2):2-12. doi: 10.1016/j.ijfoodmicro.2007.06.011. Epub 2007 Jun 13.
The availability of complete bacterial genome sequences has significantly furthered our understanding of the genetics, physiology and biochemistry of the microorganisms in question, particularly those that have commercially important applications. Bifidobacteria are among such microorganisms, as they constitute mammalian commensals of biotechnological significance due to their perceived role in maintaining a balanced gastrointestinal (GIT) microflora. Bifidobacteria are therefore frequently used as health-promoting or probiotic components in functional food products. A fundamental understanding of the metabolic activities employed by these commensal bacteria, in particular their capability to utilize a wide range of complex oligosaccharides, can reveal ways to provide in vivo growth advantages relative to other competing gut bacteria or pathogens. Furthermore, an in depth analysis of adaptive responses to nutritional or environmental stresses may provide methodologies to retain viability and improve functionality during commercial preparation, storage and delivery of the probiotic organism.
完整细菌基因组序列的可得性极大地推动了我们对相关微生物遗传学、生理学和生物化学的理解，特别是那些具有重要商业应用价值的微生物。双歧杆菌就是这类微生物之一，因其在维持胃肠道（GIT）微生物群平衡中所起的作用，它们构成了具有生物技术意义的哺乳动物共生菌。因此，双歧杆菌经常被用作功能性食品中促进健康或益生菌的成分。对这些共生菌所采用的代谢活动，特别是它们利用多种复杂寡糖的能力有基本的了解，有助于揭示相对于其他竞争性肠道细菌或病原体而言，为双歧杆菌提供体内生长优势的方法。此外，对营养或环境压力的适应性反应进行深入分析，可能会提供在益生菌商业化制备、储存和递送过程中保持其活力并改善其功能的方法。
