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研究（W）在暴露于酸和胆汁应激的双歧杆菌中的传播性。

Investigating the transmissibility of (W) in bifidobacteria exposed to acid and bile stress.

作者信息

Polit Agnieszka, Yang Huiying, Amund Daniel

机构信息

School of Life Sciences, Faculty of Health and Life Sciences, Coventry University, Priory Street, Coventry CV1 5FB, United Kingdom.

出版信息

Biosci Microbiota Food Health. 2018;37(2):39-43. doi: 10.12938/bmfh.17-017. Epub 2018 Jan 6.

DOI:10.12938/bmfh.17-017
PMID:29662736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5897239/
Abstract

Transfer of antibiotic resistance genes from probiotic bacteria to pathogens poses a safety concern. Orally administered probiotics are exposed to stressful conditions during gastrointestinal transit. In this study, filter mating experiments were performed to investigate the potential role of exposure of isolates to acid and bile stress on the transfer of a tetracycline resistance gene, (W), to ATCC 51299. No transconjugants were obtained after mating with either stressed or unstressed , thereby suggesting that (W) could not be transferred as a result of exposure to gastrointestinal stresses.

摘要

抗生素抗性基因从益生菌转移至病原体引发了安全担忧。口服的益生菌在胃肠道转运过程中会面临压力条件。在本研究中，进行了滤膜交配实验，以调查分离株暴露于酸和胆汁压力对四环素抗性基因（W）向ATCC 51299转移的潜在作用。与应激或未应激的[具体菌株名称未给出]交配后均未获得接合子，从而表明（W）不会因暴露于胃肠道压力而转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/ff01154f1178/bmfh-37-039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/a2fe69aba9b2/bmfh-37-039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/461cfbcf7c22/bmfh-37-039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/ff01154f1178/bmfh-37-039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/a2fe69aba9b2/bmfh-37-039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/461cfbcf7c22/bmfh-37-039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caaa/5897239/ff01154f1178/bmfh-37-039-g003.jpg

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