Sorgi Paul J, Hallowell Edward M, Hutchins Heather L, Sears Barry
Hallowell Center, Sudbury, MA 01776, USA.
Nutr J. 2007 Jul 13;6:16. doi: 10.1186/1475-2891-6-16.
Attention deficit hyperactivity disorder (ADHD) is the most common neurological condition in children. This pilot study evaluated the effects of high-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the isolated plasma phospholipids and behavior in children with ADHD (primarily inattentive subtype and combined subtype).
Nine children were initially supplemented with 16.2 g EPA/DHA concentrates per day. The dosage was adjusted dependent on the ratio of arachidonic acid (AA) to EPA in the isolated plasma phospholipids at four weeks to reach a level normally found in the Japanese population.
At the end of the eight-week study, supplementation resulted in significant increases in EPA and DHA, as well as a significant reduction in the AA:EPA ratio (20.78 +/- 5.26 to 5.95 +/- 7.35, p < 0.01). A psychiatrist (blind to supplement compliance or dosage modifications) reported significant improvements in behavior (inattention, hyperactivity, oppositional/defiant behavior, and conduct disorder). There was also a significant correlation between the reduction in the AA:EPA ratio and global severity of illness scores.
The findings of this small pilot study suggest supplementation with high-dose EPA/DHA concentrates may improve behavior in children with ADHD.
注意力缺陷多动障碍（ADHD）是儿童中最常见的神经疾病。这项初步研究评估了高剂量二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）补充剂对ADHD儿童（主要是注意力不集中型和混合型）的血浆磷脂和行为的影响。
9名儿童最初每天补充16.2克EPA/DHA浓缩物。根据四周时分离的血浆磷脂中花生四烯酸（AA）与EPA的比例调整剂量，以达到日本人群中正常发现的水平。
在为期八周的研究结束时，补充剂导致EPA和DHA显著增加，以及AA:EPA比例显著降低（从20.78±5.26降至5.95±7.35，p<0.01）。一位精神科医生（对补充剂依从性或剂量调整不知情）报告行为有显著改善（注意力不集中、多动、对立/违抗行为和品行障碍）。AA:EPA比例的降低与疾病总体严重程度评分之间也存在显著相关性。
这项小型初步研究的结果表明，补充高剂量EPA/DHA浓缩物可能改善ADHD儿童的行为。
