Gladkevich A, Bosker F, Korf J, Yenkoyan K, Vahradyan H, Aghajanov M
Department of Psychiatry, University Medical Centre Groningen, University Groningen, The Netherlands.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1347-55. doi: 10.1016/j.pnpbp.2007.06.005. Epub 2007 Jun 21.
The development of effective and safe drugs for a growing Alzheimer disease population is an increasing need at present. Both experimental and clinical evidence support a beneficial effect of proline-rich polypeptides in a number of neurodegenerative diseases, including Alzheimer disease. Experimental data have shown that proline-rich polypeptides isolated from bovine neurohypophisis possess neuroprotective and neuromodulatory properties in mice with aluminum neurotoxicosis or neuronal damage caused by venoms and toxins. Proline-rich polypeptides from ovine colostrums, so called Colostrinin, have been shown to produce cognitive improvement in an experimental model and in patients with Alzheimer disease. However, the precise mechanism underlying the neuroprotective action of proline-rich polypeptides is not very well established. Moreover, studies pointing at a neuroprotective effect of proline-rich polypeptides from bovine neurohypophisis in humans have not been reported thus far. The authors conclude that more detailed information on the mode of action of proline-rich polypeptides is needed as well as confirmation of their efficacy in broad clinical trials before this approach can really show its potential in the treatment of neurodegenerative disorders.
对于不断增加的阿尔茨海默病患者群体而言，开发有效且安全的药物是当前日益增长的需求。实验和临床证据均支持富含脯氨酸的多肽在包括阿尔茨海默病在内的多种神经退行性疾病中具有有益作用。实验数据表明，从牛神经垂体中分离出的富含脯氨酸的多肽在铝神经中毒或由毒液和毒素引起的神经元损伤的小鼠中具有神经保护和神经调节特性。来自羊初乳的富含脯氨酸的多肽，即所谓的初乳素，已被证明在实验模型和阿尔茨海默病患者中可改善认知功能。然而，富含脯氨酸的多肽的神经保护作用的确切机制尚未完全明确。此外，迄今为止尚未有研究报道牛神经垂体中富含脯氨酸的多肽对人类的神经保护作用。作者得出结论，在这种方法真正展现其在神经退行性疾病治疗中的潜力之前，需要更多关于富含脯氨酸的多肽作用方式的详细信息，以及在广泛的临床试验中对其疗效的确认。
