Li Tan, Fan Gui-Xiang, Wang Wei, Li Tong, Yuan Yu-Kang
Department of Immunology and Pathogenic Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, PR China.
Int Immunopharmacol. 2007 Sep;7(9):1221-31. doi: 10.1016/j.intimp.2007.05.008. Epub 2007 Jun 12.
Resveratrol, a dietary polyphenol found in grapes, has been proposed to act as a chemopreventive or anti-tumor agent in numerous epidemiologic studies. In this study, we investigate the antitumor and immunomodulation effects of resveratrol on mouse lymphocytic leukemia cells L1210 both in vitro and in vivo. Our finding indicates that resveratrol inhibits proliferation, induces apoptosis, and influences cell cycle of L1210 cells in a dose- and time-dependent manner in vitro. Furthermore, resveratrol can exert a dose-related regulatory effect on both innate and specific immune function to L1210-bearing mice. A normalization of CD4/CD8 ratios is noted as well as an enhancement of lymphocyte proliferation, NK cell activity and anti-SRBC titers. Interleukin-6 cellular content and release are suppressed by resveratrol as well as mRNA expression. In conclusion, the data provide new findings with respect to resveratrol mechanism of action to mouse lymphocytic leukemia.
白藜芦醇是一种存在于葡萄中的膳食多酚，在众多流行病学研究中被认为具有化学预防或抗肿瘤作用。在本研究中，我们研究了白藜芦醇对小鼠淋巴细胞白血病细胞L1210的体内外抗肿瘤和免疫调节作用。我们的研究结果表明，白藜芦醇在体外以剂量和时间依赖性方式抑制L1210细胞的增殖、诱导凋亡并影响其细胞周期。此外，白藜芦醇对荷L1210小鼠的固有免疫和特异性免疫功能均可发挥剂量相关的调节作用。观察到CD4/CD8比值恢复正常，同时淋巴细胞增殖、NK细胞活性和抗SRBC效价增强。白藜芦醇还可抑制白细胞介素-6的细胞含量和释放以及mRNA表达。总之，这些数据为白藜芦醇对小鼠淋巴细胞白血病的作用机制提供了新的研究结果。
