Arévalo Cindy Mayerli, Cruz-Rodriguez Nataly, Quijano Sandra, Fiorentino Susana
Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Versiti Blood Research Institute, Milwaukee, WI, United States.
Front Mol Biosci. 2023 Jul 13;10:1229760. doi: 10.3389/fmolb.2023.1229760. eCollection 2023.
Leukemic cells acquire complex and often multifactorial mechanisms of resistance to treatment, including various metabolic alterations. Although the use of metabolic modulators has been proposed for several decades, their use in clinical practice has not been established. Natural products, the so-called botanical drugs, are capable of regulating tumor metabolism, particularly in hematopoietic tumors, which could partly explain the biological activity attributed to them for a long time. This review addresses the most recent findings relating to metabolic reprogramming-Mainly in the glycolytic pathway and mitochondrial activity-Of leukemic cells and its role in the generation of resistance to conventional treatments, the modulation of the tumor microenvironment, and the evasion of immune response. In turn, it describes how the modulation of metabolism by plant-derived extracts can counteract resistance to chemotherapy in this tumor model and contribute to the activation of the antitumor immune system.
白血病细胞会获得复杂且往往是多因素的治疗耐药机制，包括各种代谢改变。尽管提出使用代谢调节剂已有数十年，但它们在临床实践中的应用尚未确立。天然产物，即所谓的植物药，能够调节肿瘤代谢，尤其是在造血肿瘤中，这在一定程度上可以解释长期以来归因于它们的生物学活性。本综述阐述了与白血病细胞代谢重编程（主要是糖酵解途径和线粒体活性）及其在对传统治疗产生耐药性、调节肿瘤微环境和逃避免疫反应中所起作用相关的最新研究结果。反过来，它描述了植物提取物对代谢的调节如何能够抵消该肿瘤模型中对化疗的耐药性，并有助于激活抗肿瘤免疫系统。
