Pan Pan, Huang Yi-Wen, Oshima Kiyoko, Yearsley Martha, Zhang Jianying, Yu Jianhua, Arnold Mark, Wang Li-Shu
Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.
J Berry Res. 2018;8(3):163-175. doi: 10.3233/JBR-180305. Epub 2018 Aug 3.
Berries and their phytochemicals have well documented chemopreventive roles, but understanding their ability to regulate cancer immunology is only beginning to be explored. The literature, including human studies, suggests that berry components can modulate our immune system to delay cancer development. Moreover, their wide spectrum of phytochemicals suggests that they might influence the functions of multiple immune cells and different aspects of cancer immunity. Cancer immune-therapies are showing promise for some types of cancer because they boost T cells' ability to recognize tumor cells - an essential prelude to destruction. Recognition occurs after dendritic cells present antigen, such as tumor antigen, to T cells, generating an adaptive response. Therefore, the potential of berries to aid cancer immune-therapies by, for example, regulating dendritic cells, warrants further investigation in animal and human studies. More information is also needed about berries' effects on the entire spectrum of immunity so that a comprehensive view can inform efforts to use berries to enhance immune responses during cancer prevention and treatment. This review summarizes the effects of berries as anti-tumor agents from the immunological perspective in tumor-bearing animals and humans.
浆果及其植物化学物质具有充分记载的化学预防作用，但对其调节癌症免疫学能力的了解才刚刚开始探索。包括人体研究在内的文献表明，浆果成分可以调节我们的免疫系统，延缓癌症发展。此外，它们种类繁多的植物化学物质表明，它们可能会影响多种免疫细胞的功能以及癌症免疫的不同方面。癌症免疫疗法对某些类型的癌症显示出前景，因为它们增强了T细胞识别肿瘤细胞的能力——这是破坏肿瘤细胞的必要前奏。识别发生在树突状细胞将抗原（如肿瘤抗原）呈递给T细胞后，从而产生适应性反应。因此，浆果通过例如调节树突状细胞来辅助癌症免疫疗法的潜力，值得在动物和人体研究中进一步探究。还需要更多关于浆果对整个免疫谱影响的信息，以便能有一个全面的认识，为利用浆果在癌症预防和治疗期间增强免疫反应的努力提供参考。本综述从免疫学角度总结了浆果在荷瘤动物和人类中作为抗肿瘤剂的作用。
