在美国，有多少性传播的艾滋病毒感染是由急性期艾滋病毒传播导致的？
How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission?
作者信息
Pinkerton Steven D
机构信息
Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 2071 North Summit Avenue, Milwaukee, WI 53202, USA.
出版信息
AIDS. 2007 Jul 31;21(12):1625-9. doi: 10.1097/QAD.0b013e32826fb6a6.
Abstract
OBJECTIVE
To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner.
METHODS
Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV.
RESULTS
Approximately 2760 (8.6%) of the estimated 32 000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections.
CONCLUSIONS
Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed.
摘要
目的
估算在美国因与急性感染性伴侣进行危险性性行为而感染艾滋病毒的人数。
方法
美国急性期艾滋病毒传播导致的新发感染人数估计值来自一个简单的数学模型，该模型将流行病学数据与有关急性感染、未意识到血清学状态的非急性感染以及知晓血清学状态的艾滋病毒感染者的相对传播率信息相结合。
结果
美国每年估计的32000例性传播艾滋病毒感染中，约2760例（8.6%）是由病毒急性期传播所致。对关键参数采用宽泛取值范围进行多变量敏感性分析得出，感染上限为5537例，占性传播感染总数的17.3%。
结论
在美国，急性期艾滋病毒传播导致的性传播感染人数比一般认为的要少。
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