Yang Zhi-Hui, Du Bin, Wei Ye-Sheng, Zhang Jun-Hui, Zhou Bin, Liang Wei-Bo, Jia Jing, Zhang Bei-Lei, Zhang Lin
Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
DNA Cell Biol. 2007 Jul;26(7):491-6. doi: 10.1089/dna.2006.0537.
X-ray repair cross-complementing groups 1 and 3 (XRCC1 and XRCC3) and xeroderma pigmentosum group D (XPD) are mainly involved in base excision repair, homologous recombination repair, and nucleotide excision repair of DNA repair pathways, respectively. Previous studies have demonstrated that their gene polymorphisms were associated with some cancer susceptibility.
To investigate the effect of XPD Lys751Gln, XRCC1 Arg399Gln, Arg194Trp, Arg280His, and XRCC3 Thr241Met polymorphisms on the risk of nasopharyngeal carcinoma (NPC), a population-based case-control study of 153 NPC patients and 168 healthy controls among Sichuan population was conducted.
Our results showed that XRCC1 codon 194 Trp allele was associated with an increased risk of NPC (odds ratio [OR] = 1.828, 95% confidence interval [CI]: 1.286-2.598), and XPD codon 751Gln allele was associated with a borderline decrease of NPC (OR = 0.600, 95% CI: 0.361-1.000); combination analysis showed that individuals with both putative genotypes of XPD codon 751 Lys/Lys and XRCC1 codon 194 Arg/Trp or Trp/Trp have a significantly elevated risk of NPC (OR = 2.708, 95% CI: 1.338-5.478).
The results indicated that XRCC1 codon 194 Trp allele and XPD codon 751 Lys allele may be contributing factors in the risk of NPC.
X射线修复交叉互补基因1和3（XRCC1和XRCC3）以及着色性干皮病D组（XPD）分别主要参与DNA修复途径中的碱基切除修复、同源重组修复和核苷酸切除修复。先前的研究表明，它们的基因多态性与某些癌症易感性相关。
为了研究XPD Lys751Gln、XRCC1 Arg399Gln、Arg194Trp、Arg280His和XRCC3 Thr241Met基因多态性对鼻咽癌（NPC）风险的影响，在四川人群中对153例NPC患者和168例健康对照进行了一项基于人群的病例对照研究。
我们的结果显示，XRCC1密码子194的Trp等位基因与NPC风险增加相关（比值比[OR]=1.828，95%置信区间[CI]：1.286 - 2.598），而XPD密码子751Gln等位基因与NPC风险呈临界降低相关（OR = 0.600，95% CI：0.361 - 1.000）；联合分析表明，XPD密码子751 Lys/Lys和XRCC1密码子194 Arg/Trp或Trp/Trp这两种假定基因型的个体患NPC的风险显著升高（OR = 2.708，95% CI：1.338 - 5.478）。
结果表明，XRCC1密码子194的Trp等位基因和XPD密码子751的Lys等位基因可能是NPC风险的促成因素。
