Varki Nissi M, Varki Ajit
Department of Pathology, Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093-0687, USA.
Lab Invest. 2007 Sep;87(9):851-7. doi: 10.1038/labinvest.3700656. Epub 2007 Jul 16.
Sialic acids (Sias) are typically found as terminal monosaccharides attached to cell surface glycoconjugates. They play many important roles in many physiological and pathological processes, including microbe binding that leads to infections, regulation of the immune response, the progression and spread of human malignancies and in certain aspects of human evolution. This review will provide some examples of these diverse roles of Sias and briefly address immunohistochemical approaches to their detection.
唾液酸（Sias）通常作为末端单糖附着于细胞表面糖缀合物上。它们在许多生理和病理过程中发挥着重要作用，包括导致感染的微生物结合、免疫反应的调节、人类恶性肿瘤的进展和扩散以及人类进化的某些方面。本综述将提供一些关于唾液酸这些多样作用的例子，并简要介绍检测它们的免疫组织化学方法。
