真菌朊病毒：遗传结构与生物学作用
Prions of fungi: inherited structures and biological roles.
作者信息
Wickner Reed B, Edskes Herman K, Shewmaker Frank, Nakayashiki Toru
机构信息
Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0830, USA.
出版信息
Nat Rev Microbiol. 2007 Aug;5(8):611-8. doi: 10.1038/nrmicro1708.
Abstract
The term 'prion' means an infectious protein that does not need an accompanying nucleic acid. There are six fungal prions, including four self-propagating amyloids and two enzymes that are necessary to activate their inactive precursors. Here we explore the scope of the prion phenomenon, the biological and evolutionary roles of prions, the structural basis of the amyloid prions and the prominent role of chaperones (proteins that affect the folding of other proteins) and other cellular components in prion generation and propagation.
摘要
“朊病毒”一词指的是一种无需伴随核酸的传染性蛋白质。有六种真菌朊病毒，包括四种自我传播的淀粉样蛋白和两种激活其无活性前体所必需的酶。在这里，我们探讨了朊病毒现象的范围、朊病毒的生物学和进化作用、淀粉样朊病毒的结构基础以及伴侣蛋白（影响其他蛋白质折叠的蛋白质）和其他细胞成分在朊病毒产生和传播中的重要作用。
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本文引用的文献
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Ure2p function is enhanced by its prion domain in Saccharomyces cerevisiae.在酿酒酵母中，Ure2p的功能通过其朊病毒结构域得到增强。
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Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure.Sup35p朊病毒结构域的淀粉样蛋白具有平行的同相β-折叠结构。
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"Prion-proof" for [PIN+]: infection with in vitro-made amyloid aggregates of Rnq1p-(132-405) induces [PIN+].针对[PIN+]的“抗朊病毒”特性：用体外制备的Rnq1p-(132 - 405)淀粉样聚集体感染可诱导[PIN+]。
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N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination.酿酒酵母eRF3的N端区域对于eRF1/eRF3复合物在翻译终止之外的功能发挥至关重要。
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A mitotically inheritable unit containing a MAP kinase module.一个包含丝裂原活化蛋白激酶模块的可通过有丝分裂遗传的单元。
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Prion proteins as genetic material in fungi.朊病毒蛋白作为真菌中的遗传物质。
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Molecular structure of amyloid fibrils: insights from solid-state NMR.淀粉样纤维的分子结构：来自固态核磁共振的见解
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