酵母朊病毒病：淀粉样结构与生物学。
Prion diseases of yeast: amyloid structure and biology.
机构信息
Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, United States.
出版信息
Semin Cell Dev Biol. 2011 Jul;22(5):469-75. doi: 10.1016/j.semcdb.2011.02.021. Epub 2011 Feb 21.
Abstract
Prion "variants" or "strains" are prions with the identical protein sequence, but different characteristics of the prion infection: e.g. different incubation periods for scrapie strains or different phenotype intensities for yeast prion variants. We have shown that infectious amyloids of the yeast prions [PSI+], [URE3] and [PIN+] each have an in-register parallel β-sheet architecture. Moreover, we have pointed out that this amyloid architecture can explain how one protein can faithfully transmit any of several conformations to new protein monomers. This explains how proteins can be genes.
摘要
朊病毒“变体”或“株系”是具有相同蛋白质序列但具有不同朊病毒感染特征的朊病毒：例如，瘙痒病株系的不同潜伏期或酵母朊病毒变体的不同表型强度。我们已经表明，酵母朊病毒[PSI+]、[URE3]和[PIN+]的传染性淀粉样蛋白都具有规则平行的β-折叠结构。此外，我们指出这种淀粉样蛋白结构可以解释一种蛋白质如何能够忠实地将几种构象之一传递给新的蛋白质单体。这解释了蛋白质如何成为基因。
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Prion amyloid structure explains templating: how proteins can be genes.朊病毒淀粉样结构解释了模板：蛋白质如何成为基因。
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A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen.通过遗传筛选检测到的酵母类半胱天冬酶同源物（Mca1p）的朊病毒。
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