Hildebrandt B, Wust P
Charité-Centrum Tumormedizin, Charité Universitätsmedizin Berlin, Germany.
Cancer Treat Res. 2007;134:171-84. doi: 10.1007/978-0-387-48993-3_10.
The clinical efficacy of various of hyperthermia approaches has been demonstrated in the scope of various randomised trials. In addition, a large body of preclinical data on alterations of cellular and molecular pathways under the circumstance of elevated temperatures is available. However, there is still uncertainty about the mechanisms which are acutally responsible for the beneficial effect of clinical hyperthermia when applied as an adjunt to radiotherapy, chemotherapy, or radiochemotherapy. This chapter gives a clinically orientated overview on the cytotoxic effect of heat alone and in conjunction with radiation and drugs, heat-induced alterations of the tumour microenvironment, and the immunological targets of hyperthermia.
各种热疗方法的临床疗效已在各种随机试验范围内得到证实。此外，有大量关于温度升高情况下细胞和分子途径改变的临床前数据。然而，当作为放疗、化疗或放化疗的辅助手段应用时，临床热疗产生有益效果的实际机制仍存在不确定性。本章对单独热疗以及热疗与放疗和药物联合应用时的细胞毒性作用、热诱导的肿瘤微环境改变以及热疗的免疫靶点进行了以临床为导向的概述。
