Ziegler H, Hauck K, Hefti A F
Arzt für Allgemeine Medizin, Winterthur.
Schweiz Monatsschr Zahnmed. 1991;101(12):1529-34.
The aim of the present study was to collect data on urinary fluoride output in 8-16-year old students exposed to either drinking water fluoridation (DWF), or domestic salt fluoridation (DSF). Spot urine samples were collected in the canton of Basel-Stadt (DWF, n = 123), in the canton of Berne (DSF, n = 264), in the county of Davos (DSF, n = 241), and in the city of Winterthur (DSF, n = 40). Furthermore, fluoride concentrations were determined in plasma samples drawn from 33 students from Winterthur. The urinary fluoride concentrations were higher in Basel and Davos (0.62 +/- 0.35 mg/l; 0.61 +/- 0.42 mg/l) than in Berne and Winterthur (0.46 +/- 0.42 mg/l; 0.50 +/- 0.31 mg/l). A relatively high natural fluoride content (0.3 mg/l) in the drinking water explained the difference in urine fluoride concentration between students from Davos and the two other regions with domestic salt fluoridation (Berne, Winterthur). The average fluoride concentration in plasma was 12.7 +/- 3.8 ng/ml. We concluded that, in general, the supply with fluoride consumed with fluoridated domestic salt is close to the level obtained with drinking water fluoridation. However, in areas with very low systemic fluoride supplementation through the drinking water this level might not be reached with salt as the only source of systemic fluoride. Also, the data confirmed the safety of domestic salt fluoridation.
本研究的目的是收集8至16岁学生的尿氟排出量数据，这些学生分别接触了饮用水氟化（DWF）或家庭食盐氟化（DSF）。在巴塞尔城市州（DWF，n = 123）、伯尔尼州（DSF，n = 264）、达沃斯县（DSF，n = 241）和温特图尔市（DSF，n = 40）采集了即时尿样。此外，还测定了从温特图尔的33名学生采集的血浆样本中的氟化物浓度。巴塞尔和达沃斯的尿氟浓度（0.62±0.35毫克/升；0.61±0.42毫克/升）高于伯尔尼和温特图尔（0.46±0.42毫克/升；0.50±0.31毫克/升）。饮用水中相对较高的天然氟含量（0.3毫克/升）解释了达沃斯的学生与其他两个采用家庭食盐氟化的地区（伯尔尼、温特图尔）之间尿氟浓度的差异。血浆中的平均氟浓度为12.7±3.8纳克/毫升。我们得出结论，一般来说，通过加氟家庭食盐摄入的氟供应接近通过饮用水氟化获得的水平。然而，在通过饮用水进行全身氟补充非常低的地区，仅以盐作为全身氟的唯一来源可能无法达到这一水平。此外，数据证实了家庭食盐氟化的安全性。
