Yang Gui-hua, Wang Fang, Zhang Jun-wu
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Jun;29(3):425-9.
MicroRNAs (miRNAs) are a family of 21-25 nucleotide small nonprotein-coding RNAs. They regulate gene expression at post-transcriptional level by mRNA degradation or translation repression. Hematopoiesis is one of the most important highly regulated multistage process, which includes orderly turn-on and turn-off of many genes; any wrong modulation may result in blood diseases. Several miRNAs have been found to be involved in hematopoiesis and hematopoietic tumor genesis.
微小RNA（miRNA）是一类由21 - 25个核苷酸组成的小型非蛋白质编码RNA。它们通过mRNA降解或翻译抑制在转录后水平调节基因表达。造血是最重要的高度调控的多阶段过程之一，其中包括许多基因的有序开启和关闭；任何错误的调节都可能导致血液疾病。已发现几种miRNA参与造血和造血肿瘤的发生。
