Kluiver J, Kroesen B-J, Poppema S, van den Berg A
Department of Pathology and Laboratory Medicine, Section Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Leukemia. 2006 Nov;20(11):1931-6. doi: 10.1038/sj.leu.2404387. Epub 2006 Sep 14.
Over the past few years, it has become evident that microRNAs (miRNAs) play an important regulatory role in various biological processes. Much effort has been put into the elucidation of their biogenesis, and this has led to the general concept that a number of key regulators are shared with the processing machinery of small interfering RNAs. Despite the recognition that several miRNAs play crucial roles in normal development and in diseases, little is known about their exact molecular function and the identity of their target genes. In this review, we report on the biological relevance of miRNAs for the differentiation of normal hematopoietic cells and on the contribution of deregulated miRNA expression in their malignant counterparts.
在过去几年中，已明显看出微小RNA（miRNA）在各种生物学过程中发挥重要的调节作用。人们已投入大量精力来阐明其生物合成过程，这导致了一个普遍概念，即一些关键调节因子与小干扰RNA的加工机制是共享的。尽管人们认识到几种miRNA在正常发育和疾病中起关键作用，但对其确切分子功能及其靶基因的身份却知之甚少。在本综述中，我们报告了miRNA对正常造血细胞分化的生物学意义以及miRNA表达失调在其恶性对应物中的作用。
