Beck-Bornholdt H P, Schmidt R, Schwarz R C, Hübener K H
Institute of Radiobiology, University of Hamburg.
Strahlenther Onkol. 1991 Dec;167(12):708-15.
The biological isoeffect distributions are calculated on the basis of the physical isodose distributions. They consider parameters of biological relevance such as the dose per fraction and the overall treatment time. A clinical example is presented to illustrate the method. The technique presented in this paper only requires minimal modifications in the conventional computer programs for treatment planning and can be updated very easily. The calculation of biological isoeffect distributions is a simple technique to facilitate the transfer of new radiobiological and clinical findings on alpha/beta ratios, tolerance doses and repopulation kinetics, into treatment planning. However, before they can be introduced into clinical practice, more reliable radiobiological data on normal tissues and tumours are required.
生物等效效应分布是根据物理等剂量分布计算得出的。它们考虑了生物相关性参数，如每次分割剂量和总治疗时间。给出了一个临床实例来说明该方法。本文介绍的技术在传统治疗计划计算机程序中只需进行最小程度的修改，并且可以非常容易地更新。生物等效效应分布的计算是一种简单的技术，有助于将关于α/β比值、耐受剂量和再增殖动力学的新放射生物学和临床研究结果应用于治疗计划。然而，在将它们引入临床实践之前，需要关于正常组织和肿瘤的更可靠的放射生物学数据。
