Li Jian, Cowden Linda G, King Janice D, Briles David A, Schroeder Harry W, Stevens Alan B, Perry Rodney T, Chen Zuomin, Simmons Micah S, Wiener Howard W, Tiwari Hemant K, Harrell Lindy E, Go Rodney C P
Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Psychosom Med. 2007 Jul-Aug;69(6):551-9. doi: 10.1097/PSY.0b013e3180cc2c61. Epub 2007 Jul 18.
To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD).
A family-based follow-up study was conducted in 119 spouses and offspring of community-dwelling patients with AD. Psychological stress was measured by the Perceived Stress Scale (PSS) and the Center for Epidemiologic Studies Depression (CES-D) scale at baseline and 1 month after the vaccination. Nutritional status, health behaviors, comorbidity, and stress-buffering factors were assessed by self-administered questionnaires, 10 single nucleotide polymorphisms (SNP) from six selected cytokines genotyped, and anti-tetanus toxoid immunoglobulin G (IgG) concentrations tested using enzyme-linked immunosorbent assays. The effects of stress and other potential confounders were assessed by mixed models that account for familial correlations.
The baseline PSS score, the baseline CES-D score, the interleukin-10-1082 A>G SNP GG genotype, and the baseline anti-tetanus IgG were inversely associated with antibody fold increase.
Both psychological stress and cytokine gene polymorphisms affected antibody fold increase. The study provided additional support for the detrimental effects of psychological stress on the antibody response to tetanus vaccine.
评估心理应激对破伤风疫苗抗体反应的影响，同时对阿尔茨海默病（AD）患者照料者的细胞因子基因多态性及其他非遗传因素进行校正。
对119名社区居住的AD患者的配偶和子女进行了一项基于家庭的随访研究。在基线期和接种疫苗后1个月，采用感知压力量表（PSS）和流行病学研究中心抑郁量表（CES-D）测量心理应激。通过自填问卷评估营养状况、健康行为、合并症和压力缓冲因素，对6种选定细胞因子的10个单核苷酸多态性（SNP）进行基因分型，并使用酶联免疫吸附测定法检测抗破伤风类毒素免疫球蛋白G（IgG）浓度。通过考虑家族相关性的混合模型评估应激和其他潜在混杂因素的影响。
基线PSS评分、基线CES-D评分、白细胞介素-10-1082 A>G SNP的GG基因型以及基线抗破伤风IgG与抗体倍增呈负相关。
心理应激和细胞因子基因多态性均影响抗体倍增。该研究为心理应激对破伤风疫苗抗体反应的有害影响提供了额外支持。
