Raison Charles L, Miller Andrew H
Department of Human Development and Family Studies, School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA.
Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Neuropsychopharmacology. 2017 Jan;42(1):5-27. doi: 10.1038/npp.2016.194. Epub 2016 Sep 15.
Significant attention has been paid to the potential adaptive value of depression as it relates to interactions with people in the social world. However, in this review, we outline the rationale of why certain features of depression including its environmental and genetic risk factors, its association with the acute phase response and its age of onset and female preponderance appear to have evolved from human interactions with pathogens in the microbial world. Approaching the relationship between inflammation and depression from this evolutionary perspective yields a number of insights that may reveal important clues regarding the origin and epidemiology of the disorder as well as the persistence of its risk alleles in the modern human genome.
抑郁症与社会世界中人与人之间的互动相关的潜在适应性价值已受到广泛关注。然而，在本综述中，我们概述了抑郁症某些特征的原理，包括其环境和遗传风险因素、与急性期反应的关联、发病年龄以及女性患病率，这些似乎都源于人类与微生物世界中病原体的相互作用。从这一进化角度探讨炎症与抑郁症之间的关系，能得出一些见解，这些见解可能揭示该疾病的起源、流行病学以及其风险等位基因在现代人类基因组中持续存在的重要线索。
