Dalziel Stuart R, Lim Vanessa K, Lambert Anthony, McCarthy Dianne, Parag Varsha, Rodgers Anthony, Harding Jane E
Clinical Trials Research Unit and Liggins Institute, University of Auckland, Auckland, New Zealand.
Dev Med Child Neurol. 2007 Aug;49(8):597-602. doi: 10.1111/j.1469-8749.2007.00597.x.
The aim of this study was to determine if preterm birth is associated with socioeconomic status (SES), psychological functioning, and health-related quality of life (HRQoL) in adulthood. We used prospective follow-up of 192 adult offspring of mothers who took part in a randomized controlled trial of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome (66 born at term [33 males, 33 females] 126 born preterm [66 males, 60 females]). Cognitive functioning was assessed using the Wechsler Abbreviated Scale of Intelligence. Working memory and attention was assessed using the Benton Visual Retention Test, the Paced Auditory Serial Addition Test, and the Brown Attention Deficit Disorder Scale. Psychiatric morbidity was assessed using the Beck Depression Inventory II, the State-Trait Anxiety Inventory, and the Schizotypy Traits Questionnaire. Handedness was assessed using the Edinburgh Handedness Inventory. HRQoL was assessed using the Short Form-36 Health Survey. Moderately preterm birth (median gestation 34wks, mean birthweight 1946g [SD 463g]) was not related to later marital status, educational attainment, SES, cognitive functioning, working memory, attention, or symptoms of anxiety or schizotypy at 31 years of age. Preterm birth was associated with fewer symptoms of depression and higher levels of satisfaction in three of the eight HRQoL domains measured (bodily pain, general health perception, and social functioning). Adults who were born moderately preterm have SES, psychological functioning, and HRQoL consistent with those who were born at term. This good long-term outcome cannot be extrapolated to those with early childhood disability or very low birthweights.
本研究的目的是确定早产是否与成年后的社会经济地位（SES）、心理功能和健康相关生活质量（HRQoL）有关。我们对192名成年后代进行了前瞻性随访，这些后代的母亲参与了一项预防新生儿呼吸窘迫综合征的产前倍他米松随机对照试验（66名足月出生[33名男性，33名女性]，126名早产[66名男性，60名女性]）。使用韦氏智力简表评估认知功能。使用本顿视觉保持测验、听觉加法定时测验和布朗注意力缺陷障碍量表评估工作记忆和注意力。使用贝克抑郁量表第二版、状态-特质焦虑量表和分裂型特质问卷评估精神疾病发病率。使用爱丁堡利手量表评估利手情况。使用简短健康调查36项量表评估健康相关生活质量。中度早产（中位孕周34周，平均出生体重1946克[标准差463克]）与31岁时的婚姻状况、教育程度、社会经济地位、认知功能、工作记忆、注意力或焦虑或分裂型症状无关。早产与所测量的八个健康相关生活质量领域中的三个领域（身体疼痛、总体健康感知和社会功能）的抑郁症状较少和满意度较高有关。中度早产出生的成年人的社会经济地位、心理功能和健康相关生活质量与足月出生的人一致。这种良好的长期结果不能外推到有儿童早期残疾或极低出生体重的人身上。
