Division of Dermatology, Department of Internal Medicine, Aging, and Nephrologic Diseases, Sant'Orsola-Malpighi Hospital, University of Bologna, Italy.
Dermatol Surg. 2013 Aug;39(8):1243-51. doi: 10.1111/dsu.12215. Epub 2013 Apr 29.
Acne affects many adolescents. Conventional therapy often results in side effects and poor adherence, and the treatment does not consider the psychological effect of acne on patients, which is comparable with that of disabling diseases.
To evaluate the efficacy and tolerability of a peel (30% salicylic acid, triethyl citrate and ethyl linoleate) combined with a home therapy with three topical agents (triethyl citrate, ethyl linoleate and salicylic acid 0.5% cream, lotion) in moderate acne of the face.
Prospective, observational, multicenter, open-label, postmarketing, phase IV study.
Patients were assessed by comparing Global Acne Grading System (GAGS) score and total lesion count from 15 days before the first peel (T-15 ), after four salicylic peels (every 10 ± 2 days (T0 , T10 , T20 , T30 ), and 20 days after of the end of the study (T50 ). This treatment was associated to a home therapy.
Fifty-three patients completed the study. The average GAGS score fell 49% between T-15 and T50 (p < .001). No patient withdrew for adverse events.
This therapy was effective and well-tolerated in all cases. Chemo-exfoliation sessions ensured the continuous monitoring of clinical results and improved patient quality of life.
痤疮影响许多青少年。常规治疗常导致副作用和较差的依从性，且治疗未考虑痤疮对患者的心理影响，这与致残性疾病相当。
评估一种（30%水杨酸、柠檬酸三乙酯和亚油酸乙酯）化学焕肤联合三种家庭治疗药物（柠檬酸三乙酯、亚油酸乙酯和 0.5%水杨酸乳膏、乳液）治疗面部中度痤疮的疗效和耐受性。
前瞻性、观察性、多中心、开放性、上市后、四期研究。
通过比较全球痤疮分级系统（GAGS）评分和总皮损计数，在第一次化学焕肤前 15 天（T-15 ）、四次水杨酸化学焕肤后（每隔 10±2 天（T0、T10、T20、T30）和研究结束后 20 天（T50）评估患者。该治疗与家庭治疗联合。
53 例患者完成了研究。T-15 至 T50 期间 GAGS 评分平均下降 49%（p<.001）。无患者因不良事件退出。
在所有病例中，该疗法均有效且耐受性良好。化学焕肤有助于持续监测临床结果并提高患者的生活质量。
