Ishiguro Atsushi, Munakata Masaki, Shitara Kohei, Suzuki Kazuhiro, Takahata Takenori, Itoh Jugoh, Sakata Yuh, Munakata Akihiro
The First Dept. of Internal Medicine, Hirosaki University School of Medicine.
Gan To Kagaku Ryoho. 2007 Jul;34(7):1127-30.
A 53-year-old woman was revealed to have gallbladder cancer with liver metastases (H 1). Since a curative operation is impossible in this case, we started systemic chemotherapy employing S-1 combined with hepatic arterial infusion using epirubicin hydrochloride and mitomycin C. After three months, the primary lesion was reduced in size. The patient has been receiving systemic chemotherapy using S-1 only as an outpatient for 16 months. Although there is not enough evidence to support standard treatment, systemic chemotherapy combined with hepatic arterial infusion would improve the survival time without deterioration of quality of life in patients with advanced gallbladder cancer. This combined therapy should be considered one of the promising strategies for advanced gallbladder cancer.
一名53岁女性被诊断为胆囊癌伴肝转移（H 1）。由于这种情况下无法进行根治性手术，我们开始采用S-1进行全身化疗，并联合肝动脉灌注盐酸表柔比星和丝裂霉素C。三个月后，原发灶缩小。患者作为门诊病人仅使用S-1进行全身化疗已达16个月。尽管没有足够证据支持标准治疗，但对于晚期胆囊癌患者，全身化疗联合肝动脉灌注可延长生存时间且不降低生活质量。这种联合治疗应被视为晚期胆囊癌有前景的治疗策略之一。
