Banerjee Ashish, Gerondakis Steve
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Immunol Cell Biol. 2007 Aug-Sep;85(6):420-4. doi: 10.1038/sj.icb.7100098. Epub 2007 Jul 17.
Toll-like receptor (TLR) signaling leads to the activation of mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways. While the upstream signaling events initiated at the level of adaptors and the activation of the downstream signaling pathways have received a lot of attention, our understanding of how these signaling pathways are coordinated to regulate gene expression is poorly understood. This review gives a selective overview on our current understanding of signaling downstream of TLRs, with an emphasis on how the upstream kinases like the mitogen-activated protein kinase kinase kinases (TAK1 and Tpl2) and inhibitor of kappa-B kinase (IKK) coordinate the signaling events that steer the course of an immune response.
Toll样受体（TLR）信号传导可导致丝裂原活化蛋白激酶和核因子-κB信号通路的激活。虽然在衔接蛋白水平启动的上游信号事件以及下游信号通路的激活已受到广泛关注，但我们对这些信号通路如何协同调节基因表达的了解却非常有限。本综述选择性地概述了我们目前对TLR下游信号传导的理解，重点关注上游激酶如丝裂原活化蛋白激酶激酶激酶（TAK1和Tpl2）和κB激酶抑制剂（IKK）如何协调引导免疫反应进程的信号事件。
