Badawey E S, Hassan A M, Kappe T
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Arch Pharm (Weinheim). 1991 Jun;324(6):355-7. doi: 10.1002/ardp.19913240607.
Barbiturates 3 as possible antimicrobial agents were obtained by reacting the N,N'-disubstituted urea 1a or the thiourea analogues 1b,c with the magic malonates 2a,b. On the other hand, reaction of 1a with ethoxycarbonyl isocyanate (4) yielded the substituted s-triazine-2,4,6(1H,3H,5H)-trione 5. The reaction of 4 with 2-aminomethyl-benzimidazole (6) gave the allophanate 7 which upon treatment with Na2CO3 yielded N-(1H-benzimidazol-2-yl)urea 8.
通过使N，N'-二取代脲1a或硫脲类似物1b、c与丙二酸衍生物2a、b反应，得到了作为潜在抗菌剂的巴比妥酸盐3。另一方面，1a与异氰酸乙酯羰基（4）反应生成取代的s-三嗪-2,4,6(1H,3H,5H)-三酮5。4与2-氨基甲基苯并咪唑（6）反应生成脲基甲酸酯7，7经碳酸钠处理后得到N-(1H-苯并咪唑-2-基)脲8。
