多瘤病毒在怀孕大鼠中诱发的血管肿瘤。

Vascular tumors induced by polyoma virus in pregnant rats.

作者信息

Vandeputte M, Meyer G, Sobis H

出版信息

J Natl Cancer Inst. 1976 Mar;56(3):517-21. doi: 10.1093/jnci/56.3.517.

DOI:10.1093/jnci/56.3.517

Abstract

Female R rats mated with an R male and inoculated in utero with polyoma virus after "fetectomy" developed tumors. These tumors originated in the uterus and were of fetal origin (visceral yolk sac). Histologically, they were hemangiomas or hemangiosarcomas. The latter were transplantable and grew in tissue culture. Infectious polyoma virus could not be isolated from the tumor cells kept as transplantable lines or cultured in vitro. However, the tumor cells were positive for the polyoma-specific surface antigen, polyoma tumor-specific transplantation antigen(s), and polyoma nuclear T antigen.

摘要

将雌性R大鼠与雄性R大鼠交配，并在“子宫切除术后”对其子宫内接种多瘤病毒，这些大鼠发生了肿瘤。这些肿瘤起源于子宫，来源于胎儿（内脏卵黄囊）。组织学上，它们是血管瘤或血管肉瘤。后者可移植并能在组织培养中生长。从作为可移植系保存或在体外培养的肿瘤细胞中无法分离出传染性多瘤病毒。然而，肿瘤细胞对多瘤病毒特异性表面抗原、多瘤病毒肿瘤特异性移植抗原和多瘤病毒核T抗原呈阳性反应。