Yang Xiao-Ying, Chen Jie, Yang Xin-Ming, Ma Shi-Ping
Department of Pharmacology of the Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210038, China.
Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):770-4.
Depression, a mental illness marked by feeling of extreme sadness, hopeless and inadequately, has been attached much importance. In this review, we summarized the research development of antidepressants, especially the active constituents, the extracts and the compound Chinese medicine of nature medicine, through consulting the relevant papers; and animal models of depression, have been utilized to screen novel drugs with antidepressant, were compared with clinical efficacy to evaluate the concordance, weak links and clinical values. Although animal models of depression fail to be unequivocally valid, also depression models generally lack both clinical and scientific credibility, they represent the tool to define potential antidepressant activity of drugs by far. Animal modeling remains a potentially important approach towards understanding neurobiological mechanisms in depression.
抑郁症是一种以极度悲伤、绝望和无能感为特征的精神疾病，已受到广泛关注。在本综述中，我们通过查阅相关文献，总结了抗抑郁药的研究进展，特别是天然药物的活性成分、提取物和复方中药；并将用于筛选新型抗抑郁药物的抑郁症动物模型与临床疗效进行比较，以评估其一致性、薄弱环节和临床价值。尽管抑郁症动物模型并非完全有效，而且抑郁症模型通常缺乏临床和科学可信度，但它们目前仍是确定药物潜在抗抑郁活性的工具。动物建模仍然是理解抑郁症神经生物学机制的一种潜在重要方法。
