Bergner Carisa L, Smolinsky Amanda N, Hart Peter C, Dufour Brett D, Egan Rupert J, Laporte Justin L, Kalueff Allan V
Department of Physiology, Georgetown University Medical School, Washington, DC, USA.
Methods Mol Biol. 2010;602:267-82. doi: 10.1007/978-1-60761-058-8_16.
Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice and their utility in screening antidepressant drugs.
抑郁症是一种常见的精神疾病，症状多样，且与其他脑功能障碍的共病率很高。由于这种复杂性，人们对抑郁症发病机制中涉及的神经和遗传机制知之甚少。在很大一部分患者中，目前的抗抑郁治疗往往无效和/或有不良副作用，这促使人们寻找更有效的药物。模拟抑郁症各种症状的动物模型在研究这种疾病的生物学机制中是不可或缺的。在这里，我们总结了几种评估小鼠抑郁样症状的常用方法及其在筛选抗抑郁药物方面的效用。
