Peinado-Manzano M A, Pozo-Garcia R
Departamento de Psicología Básica, Facultad de Psicología, Universidad de Salamanca, Spain.
Behav Brain Res. 1991 Oct 25;45(1):17-27. doi: 10.1016/s0166-4328(05)80176-7.
Male rats received either electrolytic or sham lesions bilaterally into the dorsomedial nucleus or the anterior nuclei of the thalamus or were assigned to an unoperated control group. After the postoperative recovery period all lesioned and control animals were tested for the ability to master a delayed alternation task. It was characterized by the alternation of Go and No Go trials, which were separated by intervals ranging between 0 and 80 s. Its successful performance required, firstly, the learning of the general principle that Go and No Go trials alternate with each other and secondly, in every trial, recalling the specific consequences of the responses in the previous trial after a short or long delay. Bilateral damage of the thalamus including the dorsomedial nucleus or anterior nuclei severely disrupted the performance of a delayed alternation task. A detailed analysis of the performance throughout the training suggests that the impairment associated with both thalamic lesions could be interpreted as a deficit in recalling specific information. This analysis also reveals a failure in the early stages of learning. Further research concerning the role of the dorsomedial nucleus and the anterior nuclei of the thalamus in learning and memory is proposed as necessary.
雄性大鼠双侧接受丘脑背内侧核或前核的电解损伤或假损伤，或被分配到未手术的对照组。术后恢复期后，对所有损伤组和对照组动物进行掌握延迟交替任务能力的测试。该任务的特点是“去”和“不去”试验交替进行，试验间隔时间在0至80秒之间。成功完成该任务首先需要学习“去”和“不去”试验相互交替的一般原则，其次在每次试验中，在短时间或长时间延迟后回忆前一次试验中反应的具体结果。包括背内侧核或前核在内的丘脑双侧损伤严重破坏了延迟交替任务的表现。对整个训练过程中表现的详细分析表明，与两种丘脑损伤相关的损伤可解释为回忆特定信息的缺陷。该分析还揭示了学习早期阶段的失败。有必要对丘脑背内侧核和前核在学习和记忆中的作用进行进一步研究。
