Peinado-Manzano M A
Departamento de Psicología, Facultad de Filosofía y Ciencias de la Educación, Universidad de Salamanca, Spain.
Behav Brain Res. 1990 May 7;38(2):117-34. doi: 10.1016/0166-4328(90)90010-c.
Male rats received either electrolytic or sham lesions bilaterally into the amygdala, hippocampus or amygdala plus hippocampus, or were assigned to an unoperated control group. After the postoperative recovery period all lesioned and control animals were tested for the ability to master a spatial delayed non-matching-to-sample (DNMS), a visual DNMS and a visuo-tactile DNMS. Retention of these paradigms was evaluated 24 h after the last respective training session. Bilateral lesions of the amygdala severely disrupted the acquisition and retention of a DNMS paradigm with visual and visuo-tactile cues as discriminative stimuli and had no effect on the acquisition and retention of a spatial DNMS. On the contrary, bilateral lesions of the hippocampus impaired the acquisition and retention of spatial DNMS, but the animals with these lesions showed an acquisition and retention of the visual and visuo-tactile DNMS paradigms significantly better than those of animals with amygdala lesions. Combined lesions of the amygdala and hippocampus severely disrupted the acquisition and retention of the 3 paradigms. The contribution of the amygdala and the hippocampus in the working memory for spatial and non-spatial information is discussed.
雄性大鼠双侧杏仁核、海马或杏仁核加海马接受电解损伤或假损伤，或被分配到未手术的对照组。术后恢复期后，对所有损伤组和对照组动物进行空间延迟非匹配样本（DNMS）、视觉DNMS和视觉-触觉DNMS的掌握能力测试。在最后一次相应训练 session 后24小时评估这些范式的记忆保持情况。杏仁核双侧损伤严重破坏了以视觉和视觉-触觉线索作为辨别刺激的DNMS范式的习得和记忆保持，对空间DNMS的习得和记忆保持没有影响。相反，海马双侧损伤损害了空间DNMS的习得和记忆保持，但有这些损伤的动物在视觉和视觉-触觉DNMS范式的习得和记忆保持方面明显优于杏仁核损伤的动物。杏仁核和海马的联合损伤严重破坏了这三种范式的习得和记忆保持。讨论了杏仁核和海马在空间和非空间信息工作记忆中的作用。
