Tadesse Abilo, Negash Mekonnen, Ketema Late Shimeles
Gondar University , P.O. Box 196, Gondar, Ethiopia.
Ethiop Med J. 2007 Apr;45(2):143-9.
To estimate the prevalence of asymptomatic bacteriuria in pregnant women, identify the frequently isolated uropathogenic bacteria and its antimicrobial sensitivity pattern.
This cross-sectional case series study was conducted in antenatal care clinic of Gondar Teaching Hospital from June-Oct., 2001. One hundred and seventy three pregnant women, who met the inclusion criteria, were included in the study after informed consent was obtained Clinical information pertaining to socio demographic data and obstetric history was filled in the questionnaire, pertinent physical examination was done and urine specimen from each candidate was collected and processed following the standard microbiological technique.
Majority (70-90%) of the pregnant women were literate, housewives, married and residents of Gondar town. Of all pregnant women included in the study, 96/173 (56%) were multigravida, and 21/173 (12%) had 5 or more pregnancies. The identification rate of significant bacteriuria in the study group was 9.8% (17/173) with higher rate (20.5%) in multiparous mothers. The frequently isolated urinary pathogenic bacteria was E. coli, 47% (8/17), followed by S. aureus 3/17 (18%) and C. freundi 2/17 (12%). The majority of E. coli isolates (50-75%) were resistant to gentamicin, Ampicillin, trimethoprim-sulphamethoxazole, tetracycline, and chloramphenicol; while 75% and 100% of E. coli isolates were sensitive to cefoxitin, and ciprofloxacin respectively.
Asymptomatic bacteriuria in pregnant women was prevalent in the study locality. E. coli was the common isolated urinary pathogen among urine samples of study subjects, and was found to be resistant to multiple antimicrobial agents. We suggest cefoxitin should be the drug used to treat significant bacteriuria in pregnant women in the study locality.
评估孕妇无症状菌尿的患病率，确定常见的尿路致病细菌及其抗菌药敏模式。
本横断面病例系列研究于2001年6月至10月在贡德尔教学医院的产前保健诊所进行。173名符合纳入标准的孕妇在获得知情同意后被纳入研究。在问卷中填写了与社会人口统计学数据和产科病史相关的临床信息，进行了相关体格检查，并按照标准微生物技术收集和处理了每位受试者的尿液样本。
大多数（70 - 90%）孕妇识字、为家庭主妇、已婚且居住在贡德尔镇。在纳入研究的所有孕妇中，96/173（56%）为经产妇，21/173（12%）有5次或更多次妊娠。研究组中显著菌尿的识别率为9.8%（17/173），经产妇中的发生率更高（20.5%）。常见的尿路致病细菌为大肠杆菌，占47%（8/17），其次是金黄色葡萄球菌，占3/17（18%），弗氏柠檬酸杆菌占2/17（12%）。大多数大肠杆菌分离株（50 - 75%）对庆大霉素、氨苄西林、甲氧苄啶 - 磺胺甲恶唑、四环素和氯霉素耐药；而75%和100%的大肠杆菌分离株分别对头孢西丁和环丙沙星敏感。
研究地区孕妇无症状菌尿较为普遍。大肠杆菌是研究对象尿液样本中常见的尿路致病病原体，且对多种抗菌药物耐药。我们建议头孢西丁应作为研究地区治疗孕妇显著菌尿的药物。
