Shobhana A, Guha S K, Neogi D K
Department of Tropical Medicine, School of Tropical Medicine, Kolkata.
Indian J Dermatol Venereol Leprol. 2004 Mar-Apr;70(2):82-6.
Human immunodeficiency virus (HIV) is associated with various mucocutaneous features, which may be the first pointer towards the existence of HIV infection. This study was done to note the different mucocutaneous lesions present in the HIV population in eastern India.
Four hundred and ten HIV seropositive patients attending the outpatient and inpatient departments were included in the study.
Out of 410 HIV positives, 40% had mucocutaneous involvement at presentation. The mean age of the study population was 29 years and male to female ratio was 2.5:1. The common mucocutaneous morbidities included oral candidiasis (36%), dermatophytosis and gingivitis (13% each), herpes zoster (6%), herpes simplex and scabies (5% each). A striking feature, noted in 36% males, was straightening of hairs. Genital herpes was the commonest genital ulcer disease. Lesions associated with declining immunity included oral candidiasis, oral hairy leukoplakia and herpes zoster with median CD4 counts of 98, 62 and 198/ L respectively.
Early recognition of mucocutaneous manifestations and associated STDs help in better management of HIV/AIDS.
人类免疫缺陷病毒(HIV)与多种皮肤黏膜特征相关,这些特征可能是HIV感染存在的首个迹象。本研究旨在记录印度东部HIV人群中出现的不同皮肤黏膜病变。
本研究纳入了410名在门诊和住院部就诊的HIV血清学阳性患者。
在410名HIV阳性患者中,40%在就诊时存在皮肤黏膜受累情况。研究人群的平均年龄为29岁,男女比例为2.5:1。常见的皮肤黏膜疾病包括口腔念珠菌病(36%)、皮肤癣菌病和牙龈炎(各13%)、带状疱疹(6%)、单纯疱疹和疥疮(各5%)。在36%的男性患者中观察到一个显著特征,即毛发变直。生殖器疱疹是最常见的生殖器溃疡疾病。与免疫功能下降相关的病变包括口腔念珠菌病、口腔毛状白斑和带状疱疹,其CD4细胞计数中位数分别为98、62和198/μL。
早期识别皮肤黏膜表现及相关性传播疾病有助于更好地管理HIV/AIDS。