Sindrup J H, Weismann K, Sand Petersen C, Rindum J, Pedersen C, Mathiesen L, Worm A M, Kroon S, Søndergaard J, Lange Wantzin G
Department of Dermato-venerology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Acta Derm Venereol. 1988;68(5):440-3.
During a 6-month-period, 150 patients infected with Human Immunodeficiency Virus (HIV) were repeatedly examined by dermatologists and dentists for lesions of skin and oral mucosa. The most frequently encountered diseases were: oral hairy leukoplakia (21%), dermatophytosis (including tinea unguium/tinea pedis et inguinalis) (20%), seborrheic dermatitis (19%), viral infections (10%), oral candidiasis (7%), acne vulgaris (6%), and folliculitis (5%). A variety of other manifestations were seen, with frequencies less than 5%. Herpes zoster was seen in 3% of the patients, indicating a rate of 60/1,000 per annum. The presence of seborrheic dermatitis was statistically associated with low T-helper lymphocyte count. Patients with low T-helper lymphocyte count had on average twice as many mucocutaneous lesions as patients with a normal or moderately decreased count. Any one of the manifestations seborrheic dermatitis, oral candidiasis or oral hairy leukoplakia was associated with a greater average number of additional mucocutaneous changes than seen in patients exhibiting none of these three conditions. The high proportion of HIV-infected patients with cutaneous and oral lesions underlines the importance of referring the patients to dermatologists and dentists for examination. Prospective examinations of the study population remain to elucidate the prognostic significance of mucocutaneous manifestations of HIV-infected patients.
在6个月的时间里，皮肤科医生和牙医对150名感染人类免疫缺陷病毒（HIV）的患者进行了多次皮肤和口腔黏膜病变检查。最常见的疾病有：口腔毛状白斑（21%）、皮肤癣菌病（包括甲癣/足癣和股癣）（20%）、脂溢性皮炎（19%）、病毒感染（10%）、口腔念珠菌病（7%）、寻常痤疮（6%）和毛囊炎（5%）。还观察到了各种其他表现，其发生率低于5%。3%的患者出现带状疱疹，表明年发病率为60/1000。脂溢性皮炎的存在与低辅助性T淋巴细胞计数在统计学上相关。辅助性T淋巴细胞计数低的患者黏膜皮肤病变的数量平均是计数正常或中度降低患者的两倍。脂溢性皮炎、口腔念珠菌病或口腔毛状白斑中的任何一种表现与额外黏膜皮肤变化的平均数量增加有关，比未出现这三种情况的患者更为明显。感染HIV的患者中皮肤和口腔病变比例高，凸显了将患者转诊给皮肤科医生和牙医进行检查的重要性。对研究人群进行前瞻性检查仍有待阐明HIV感染患者黏膜皮肤表现的预后意义。
