Roselli Charles F
Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.
J Steroid Biochem Mol Biol. 2007 Aug-Sep;106(1-5):143-50. doi: 10.1016/j.jsbmb.2007.05.014. Epub 2007 May 24.
It is well established that aromatization constitutes an essential part of testosterone's signaling pathway in brain and that estrogen metabolites, often together with testosterone, organize and activate masculine neural circuits. This paper summarizes the current understanding regarding the distribution, regulation and function of brain aromatase in mammals. Data from our laboratory are presented that highlight the important function of aromatase in the regulation of androgen feedback sensitivity in non-human primates and the possible role that aromatase plays in determining the brain structure and sexual partner preferences of rams. In addition, new data is presented indicating that the capacity for aromatization in cortical astrocytes is associated with cell survival and may be important for neuroprotection. It is anticipated that a better appreciation of the physiological and pathophysiological functions of aromatase will lead to important clinical insights.
众所周知，芳香化作用是睾酮在大脑中信号通路的重要组成部分，雌激素代谢产物通常与睾酮一起，构建并激活雄性神经回路。本文总结了目前对哺乳动物脑芳香化酶的分布、调节和功能的认识。展示了我们实验室的数据，这些数据突出了芳香化酶在调节非人类灵长类动物雄激素反馈敏感性方面的重要作用，以及芳香化酶在决定公羊大脑结构和性伴侣偏好中可能发挥的作用。此外，还展示了新数据，表明皮质星形胶质细胞中的芳香化能力与细胞存活相关，可能对神经保护很重要。预计对芳香化酶生理和病理生理功能的更好理解将带来重要的临床见解。
