Garcia-Segura L M
Instituto Cajal, CSIC, Madrid, Spain.
J Neuroendocrinol. 2008 Jun;20(6):705-12. doi: 10.1111/j.1365-2826.2008.01713.x.
Aromatase, the enzyme that synthesises oestrogens from androgen precursors, is expressed in the brain, where it has been classically associated with the regulation of neuroendocrine events and behaviours linked with reproduction. Recent findings, however, have revealed new unexpected roles for brain aromatase, indicating that the enzyme regulates synaptic activity, synaptic plasticity, neurogenesis and the response of neural tissue to injury, and may contribute to control nonreproductive behaviours, mood and cognition. Therefore, the function of brain aromatase is not restricted to the regulation of reproduction as previously thought.
芳香化酶是一种将雄激素前体合成为雌激素的酶，在大脑中表达，传统上它与神经内分泌事件的调节以及与生殖相关的行为有关。然而，最近的研究结果揭示了大脑芳香化酶新的意想不到的作用，表明该酶调节突触活动、突触可塑性、神经发生以及神经组织对损伤的反应，并且可能有助于控制非生殖行为、情绪和认知。因此，大脑芳香化酶的功能并不局限于如先前认为的那样仅调节生殖。
